Apopka is a city in Orange County, Florida. The city's population was 41,542 at the 2010 census, up from 26,969 at the 2000 U.S. Census. It is part of the OrlandoKissimmeeSanford Metropolitan Statistical Area. Apopka is a Seminole word for "Potato eating place". Apopka is often referred to as the "Indoor Foliage Capital of the World". The earliest known inhabitants of the Apopka area were the Acuera people, members of the Timucua confederation. They had disappeared by 1730, probably decimated by diseases brought to Florida by Spanish colonists.